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As Senior Consultant Cardiologist at the National University Heart Centre, Singapore (NUHCS), Vice-Dean (Research) at the NUS Yong Loo Lin School of Medicine, Zayed bin Sultan Al Nahyan Professor of Medicine, Group Director Research, NUHS, and Director of the NUS Cardiovascular Research Institute (CVRI), Prof Roger Foo has long stood at the forefront of cardiovascular genomics and precision medicine in Asia. While his career spans decades of groundbreaking bench-to-bedside research in cardiac epigenetics, his current focus is directed at a broader, population-level imperative: shifting healthcare from reactive disease treatment to proactive, personalised prevention.

At the heart of this vision is Project RESET (Redirecting immune, lipid and metabolic drivers of early cardiovascular disease), a major nationwide initiative headed by Prof Foo.

Supported by a S$25 million grant from the National Research Foundation (NRF) and the Ministry of Health’s National Medical Research Council (NMRC), Project RESET is a 5-year collaborative research initiative involving top medical schools, public healthcare clusters, and research institutes across Singapore.

Project RESET investigates the interconnected cardio-liver-metabolic axis so as to enable clinicians to identify heart disease in patients before it becomes an emergency, capturing data on:

• Subclinical Heart Conditions: Early Left Ventricular (LV) muscle fibrosis and arterial plaque.
• Metabolic & Liver Function: Fatty liver disease (MASLD) and metabolic flexibility.
• Multi-Omic Biomarkers: Genetic, transcriptomic, and metabolic markers specific to Asian ethnicities.